Kochi international airport (Nedumbassery) is 80 kms from Guruvayur and the Calicut (Kozhikode) airport is 100 kms away. All major international flight services are operated from these airports.

Guruvayur has got a railway station towards the east of the temple which is connected to the Madras-Mangalore main line at Thrissur. Tourists coming from the Madras/ Trivandrum area can get down at Thrissur, just 29 km away, around one to one and a half hour drive from Guruvayur, and tourists from Mangalore side can get down at the Kuttippram station. Regular bus services are available from these places to Guruvayur.

Guruvayur is well connected with the other parts of the country by road. KSRTC bus stand is 500metres to the west of the temple and the private bus stand towards the east. The National highway is passing through Kunnamkulam which is just 8 kms away from Guruvayur. Several state owned and private buses, as well as taxis and other vehicles regularly ply between Trichur and Guruvayur. Bus connections are also available with all important towns of Kerala as well as neighbouring Karnataka, and Tamil Nadu via Trichur.